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R ETURN O F T HE GDI: The GoLoco Motif in Cell Division

Willard, Francis S., Kimple, Randall J., Siderovski, David P.

Journal:

Annual Review of Biochemistry

Année:

2004

Langue:

english

Fichier:

PDF, 1.55 MB

english, 2004

Regulators of G-Protein Signaling and Their G Substrates: Promises and Challenges in Their Use as Drug Discovery Targets

Kimple, A. J., Bosch, D. E., Giguere, P. M., Siderovski, D. P.

Journal:

Pharmacological Reviews

Année:

2011

Langue:

english

Fichier:

PDF, 3.14 MB

english, 2011

Development of full sweet, umami, and bitter taste responsiveness requires Regulator of G protein Signaling-21 (RGS21)

Schroer, Adam B, Gross, Joshua D, Kaski, Shane W, Wix, Kim, Siderovski, David P, Vandenbeuch, Aurelie, Setola, Vincent

Journal:

Chemical Senses

Année:

2018

Langue:

english

Fichier:

PDF, 1.36 MB

english, 2018

Differential expression of regulator of G-protein signaling R12 subfamily members during mouse development

Luke Martin-McCaffrey, Melinda D. Hains, Grant A. Pritchard, Agnieszka Pajak, Lina Dagnino, David P. Siderovski, Sudhir J.A. D'Souza

Journal:

Developmental Dynamics

Année:

2005

Langue:

english

Fichier:

PDF, 2.79 MB

english, 2005

RAMHA: A PC-based Monte-Carlo simulation of random saturation mutagenesis

David P. Siderovski, Tak W. Mak

Journal:

Computers in Biology and Medicine

Année:

1993

Langue:

english

Fichier:

PDF, 1.05 MB

english, 1993

The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Gα-interaction face

Adam J. Kimple, Francis S. Willard, Patrick M. Giguère, Christopher A. Johnston, Viorel Mocanu, David P. Siderovski

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Année:

2007

Langue:

english

Fichier:

PDF, 796 KB

english, 2007

A direct fluorescence-based assay for RGS domain GTPase accelerating activity

Francis S. Willard, Adam J. Kimple, Christopher A. Johnston, David P. Siderovski

Journal:

Analytical Biochemistry

Année:

2005

Langue:

english

Fichier:

PDF, 844 KB

english, 2005

Covalent immobilization of histidine-tagged proteins for surface plasmon resonance

Francis S. Willard, David P. Siderovski

Journal:

Analytical Biochemistry

Année:

2006

Langue:

english

Fichier:

PDF, 148 KB

english, 2006

G-protein signaling: back to the future

C. R. McCudden, M. D. Hains, R. J. Kimple, D. P. Siderovski, F. S. Willard

Journal:

Cellular and Molecular Life Sciences

Année:

2005

Langue:

english

Fichier:

PDF, 555 KB

english, 2005

D2 dopamine receptor activation of potassium channels is selectively decoupled by Gαi-specific GoLoco motif peptides

Christina K. Webb, Christopher R. McCudden, Francis S. Willard, Randall J. Kimple, David P. Siderovski, Gerry S. Oxford

Journal:

Journal of Neurochemistry

Année:

2005

Langue:

english

Fichier:

PDF, 340 KB

english, 2005

Structural determinants for GoLoco-induced inhibition of nucleotide release by Gα subunits

Kimple, Randall J., Kimple, Michelle E., Betts, Laurie, Sondek, John, Siderovski, David P.

Journal:

Nature

Année:

2002

Langue:

english

Fichier:

PDF, 381 KB

english, 2002

Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins

Wang, Hongyan, Ng, Kian Hong, Qian, Hongliang, Siderovski, David P., Chia, William, Yu, Fengwei

Journal:

Nature Cell Biology

Année:

2005

Langue:

english

Fichier:

PDF, 1.02 MB

english, 2005

Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism

Lambert, John M., Lambert, Que T., Reuther, Gary W., Malliri, Angeliki, Siderovski, David P., Sondek, John, Collard, John G., Der, Channing J.

Journal:

Nature Cell Biology

Année:

2002

Langue:

english

Fichier:

PDF, 310 KB

english, 2002

Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure

Tang, Mary, Wang, Guang, Lu, Ping, Karas, Richard H, Aronovitz, Mark, Heximer, Scott P, Kaltenbronn, Kevin M, Blumer, Kendall J, Siderovski, David P, Zhu, Yan

Journal:

Nature Medicine

Année:

2003

Langue:

english

Fichier:

PDF, 350 KB

english, 2003

REGULATORS OF G-PROTEIN SIGNALLING AS NEW CENTRAL NERVOUS SYSTEM DRUG TARGETS

Neubig, Richard R., Siderovski, David P.

Journal:

Nature Reviews Drug Discovery

Année:

2002

Langue:

english

Fichier:

PDF, 998 KB

english, 2002

Structural basis for the selective activation of Rho GTPases by Dbl exchange factors

Snyder, Jason T., Worthylake, David K., Rossman, Kent L., Betts, Laurie, Pruitt, Wendy M., Siderovski, David P., Der, Channing J., Sondek, John

Journal:

Natural Structural Biology

Année:

2002

Langue:

english

Fichier:

PDF, 1.31 MB

english, 2002

Crystal structure of the multifunctional Gβ5–RGS9 complex

Cheever, Matthew L, Snyder, Jason T, Gershburg, Svetlana, Siderovski, David P, Harden, T Kendall, Sondek, John

Journal:

Nature Structural and Molecular Biology

Année:

2008

Langue:

english

Fichier:

PDF, 1.26 MB

english, 2008

Rgs1 regulates multiple Gα subunits in Magnaporthe pathogenesis, asexual growth and thigmotropism

Liu, Hao, Suresh, Angayarkanni, Willard, Francis S, Siderovski, David P, Lu, Shen, Naqvi, Naweed I

Journal:

The EMBO Journal

Année:

2007

Langue:

english

Fichier:

PDF, 617 KB

english, 2007

Selective role for RGS12 as a Ras/Raf/MEK scaffold in nerve growth factor-mediated differentiation

Willard, Melinda D, Willard, Francis S, Li, Xiaoyan, Cappell, Steven D, Snider, William D, Siderovski, David P

Journal:

The EMBO Journal

Année:

2007

Langue:

english

Fichier:

PDF, 392 KB

english, 2007

LGN regulates mitotic spindle orientation during epithelial morphogenesis

Zheng, Z., Zhu, H., Wan, Q., Liu, J., Xiao, Z., Siderovski, D. P., Du, Q.

Journal:

The Journal of Cell Biology

Année:

2010

Langue:

english

Fichier:

PDF, 4.28 MB

english, 2010

HIV-1 Tat Directly Interacts with the Interferon-Induced, Double-Stranded RNA-Dependent Kinase, PKR

NIGEL A.J. MCMILLAN, RENE F. CHUN, DAVID P. SIDEROVSKI, JULIEN GALABRU, W.MARK TOONE, CHARLES E. SAMUEL, TAK W. MAK, ARA G. HOVANESSIAN, KUAN-TEH JEANG, BRYAN R.G. WILLIAMS

Journal:

Virology

Année:

1995

Langue:

english

Fichier:

PDF, 238 KB

english, 1995

Gα selectivity and inhibitor function of the multiple GoLoco motif protein GPSM2/LGN

Christopher R. McCudden, Francis S. Willard, Randall J. Kimple, Christopher A. Johnston, Melinda D. Hains, Miller B. Jones, David P. Siderovski

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Année:

2005

Langue:

english

Fichier:

PDF, 666 KB

english, 2005

G-protein alpha subunit interaction and guanine nucleotide dissociation inhibitor activity of the dual GoLoco motif protein PCP-2 (Purkinje cell protein-2)

Francis S. Willard, Christopher R. McCudden, David P. Siderovski

Journal:

Cellular Signalling

Année:

2006

Langue:

english

Fichier:

PDF, 377 KB

english, 2006

The effect of RGS12 on PDGFβ receptor signalling to p42/p44 mitogen activated protein kinase in mammalian cells

Balwinder S. Sambi, Melinda D. Hains, Catherine M. Waters, Michelle C. Connell, Francis S. Willard, Adam J. Kimple, Susan Pyne, David P. Siderovski, Nigel J. Pyne

Journal:

Cellular Signalling

Année:

2006

Langue:

english

Fichier:

PDF, 583 KB

english, 2006

Differential G-alpha interaction capacities of the GoLoco motifs in Rap GTPase activating proteins

Francis S. Willard, Aaron B. Low, Christopher R. McCudden, David P. Siderovski

Journal:

Cellular Signalling

Année:

2007

Langue:

english

Fichier:

PDF, 1018 KB

english, 2007

RETRACTED: Structure of the Parathyroid Hormone Receptor C Terminus Bound to the G-Protein Dimer Gβ1γ2

Christopher A. Johnston, Adam J. Kimple, Patrick M. Giguère, David P. Siderovski

Journal:

Structure

Année:

2008

Langue:

english

Fichier:

PDF, 2.03 MB

english, 2008

Retraction Notice to: Structure of the Parathyroid Hormone Receptor C Terminus Bound to the G-Protein Dimer Gβ1γ2

Christopher A. Johnston, Adam J. Kimple, Patrick M. Giguère, David P. Siderovski

Journal:

Structure

Année:

2011

Fichier:

PDF, 37 KB

2011

Gγ-like (ggl) domains: new frontiers in g-protein signaling and β-propeller scaffolding

John Sondek, David P. Siderovski

Journal:

Biochemical Pharmacology

Année:

2001

Langue:

english

Fichier:

PDF, 880 KB

english, 2001

Role of the pleckstrin homology domain in intersectin-L Dbl homology domain activation of Cdc42 and signaling

Wendy M. Pruitt, Antoine E. Karnoub, A.Corinne Rakauskas, Michel Guipponi, Stylianos E. Antonarakis, Alexei Kurakin, Brian K. Kay, John Sondek, David P. Siderovski, Channing J. Der

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Année:

2003

Langue:

english

Fichier:

PDF, 247 KB

english, 2003

The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo

Y Liu, B.E Snow, M.P Hande, D Yeung, N.J Erdmann, A Wakeham, A Itie, D.P Siderovski, P.M Lansdorp, M.O Robinson, L Harrington

Journal:

Current Biology

Année:

2000

Langue:

english

Fichier:

PDF, 388 KB

english, 2000

A new family of regulators of G-protein-coupled receptors?

David P. Siderovski, Andrew Hessel, Stephen Chung, Tak W. Mak, Michael Tyers

Journal:

Current Biology

Année:

1996

Langue:

english

Fichier:

PDF, 982 KB

english, 1996

The GoLoco motif: a Gαi/o binding motif and potential guanine-nucleotide exchange factor

David P. Siderovski, Marı́a A. Diversé-Pierluissi, Luc De Vries

Journal:

Trends in Biochemical Sciences

Année:

1999

Langue:

english

Fichier:

PDF, 431 KB

english, 1999

Molecular Cloning and Expression Analysis of RatRgs12andRgs14

Bryan E. Snow, Laarni Antonio, Sid Suggs, Howard B. Gutstein, David P. Siderovski

Journal:

Biochemical and Biophysical Research Communications

Année:

1997

Langue:

english

Fichier:

PDF, 439 KB

english, 1997

Cloning of Human Lymphocyte-Specific Interferon Regulatory Factor (hLSIRF/hIRF4) and Mapping of the Gene to 6p23–p25

Alex Grossman, Hans-Willi Mittrücker, Jillian Nicholl, Akira Suzuki, Stephen Chung, Laarni Antonio, Sid Suggs, Grant R. Sutherland, David P. Siderovski, Tak W. Mak

Journal:

Genomics

Année:

1996

Langue:

english

Fichier:

PDF, 242 KB

english, 1996

Cooperative interaction between the DNA-binding domains of PU.1 and IRF4

Adelinda A Yee, Peter Yin, David P Siderovski, Tak W Mak, David W Litchfield, Cheryl H Arrowsmith

Journal:

Journal of Molecular Biology

Année:

1998

Langue:

english

Fichier:

PDF, 433 KB

english, 1998

The R6A-1 peptide binds to switch II of Gαi1 but is not a GDP-dissociation inhibitor

Francis S. Willard, David P. Siderovski

Journal:

Biochemical and Biophysical Research Communications

Année:

2006

Langue:

english

Fichier:

PDF, 215 KB

english, 2006

RIC-8 Is Required for GPR-1/2-Dependent Gα Function during Asymmetric Division of C. elegans Embryos

Katayoun Afshar, Francis S. Willard, Kelly Colombo, Christopher A. Johnston, Christopher R. McCudden, David P. Siderovski, Pierre Gönczy

Journal:

Cell

Année:

2004

Langue:

english

Fichier:

PDF, 701 KB

english, 2004

A bifunctional Gαi/Gαs modulatory peptide that attenuates adenylyl cyclase activity

Christopher A. Johnston, J. Kevin Ramer, Rainer Blaesius, Zoey Fredericks, Val J. Watts, David P. Siderovski

Journal:

FEBS Letters

Année:

2005

Langue:

english

Fichier:

PDF, 396 KB

english, 2005

The Mitochondrial Proteins NLRX1 and TUFM Form a Complex that Regulates Type I Interferon and Autophagy

Yu Lei, Haitao Wen, Yanbao Yu, Debra J. Taxman, Lu Zhang, Douglas G. Widman, Karen V. Swanson, Kwun-Wah Wen, Blossom Damania, Chris B. Moore, Patrick M. Giguère, David P. Siderovski, John Hiscott, Bab

Journal:

Immunity

Année:

2012

Langue:

english

Fichier:

PDF, 2.08 MB

english, 2012

Structural and Evolutionary Division of Phosphotyrosine Binding (PTB) Domains

Mark T. Uhlik, Brenda Temple, Sompop Bencharit, Adam J. Kimple, David P. Siderovski, Gary L. Johnson

Journal:

Journal of Molecular Biology

Année:

2005

Langue:

english

Fichier:

PDF, 2.03 MB

english, 2005

Structure-based Protocol for Identifying Mutations that Enhance Protein–Protein Binding Affinities

Deanne W. Sammond, Ziad M. Eletr, Carrie Purbeck, Randall J. Kimple, David P. Siderovski, Brian Kuhlman

Journal:

Journal of Molecular Biology

Année:

2007

Langue:

english

Fichier:

PDF, 1.57 MB

english, 2007

Mammalian Inscuteable Regulates Spindle Orientation and Cell Fate in the Developing Retina

Mihaela Žigman, Michel Cayouette, Christoforos Charalambous, Alexander Schleiffer, Oliver Hoeller, Dara Dunican, Christopher R. McCudden, Nicole Firnberg, Ben A. Barres, David P. Siderovski, Juergen A

Journal:

Neuron

Année:

2005

Langue:

english

Fichier:

PDF, 524 KB

english, 2005

Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

Vuk Stambolic, Akira Suzuki, José Luis de la Pompa, Greg M Brothers, Christine Mirtsos, Takehiko Sasaki, Jurgen Ruland, Josef M Penninger, David P Siderovski, Tak W Mak

Journal:

Cell

Année:

1998

Langue:

english

Fichier:

PDF, 998 KB

english, 1998

Cloning of a retinally abundant regulator of G-protein signaling (RGS-r/RGS16): genomic structure and chromosomal localization of the human gene

Bryan E Snow, Laarni Antonio, Sid Suggs, David P Siderovski

Journal:

Gene

Année:

1998

Langue:

english

Fichier:

PDF, 479 KB

english, 1998

10.1038/35047093

Diversé-Pierluissi, María, Schiff, Max L., Siderovski, David P., Jordan, J. Dedrick, Brothers, Greg, Snow, Bryan, De Vries, Luc, Ortiz, Daniel F.

Journal:

Nature

Année:

2000

Langue:

english

Fichier:

PDF, 248 KB

english, 2000

G Protein Coupled Receptor Kinase 3 (GRK3) - Deficient T Cells Demonstrate Enhanced Migration To CXCL12 And CX3CL1

Rothlein, L.R., Timoshchenko, R.G., Fitzhugh, D.J., McGinnis, M.W., Laroche, G., Siderovski, D.P., Tarrant, T.K.

Journal:

Journal of Allergy and Clinical Immunology

Année:

2011

Langue:

english

Fichier:

PDF, 41 KB

english, 2011

Immunologic Phenotype Of GRK3-null Mice At Baseline And In Inflammatory Disease

Timoshchencko, R.G., Rothlein, L.R., McGinnis, M.W., Foreman, O., Esserman, D., Lee, D.M., Patel, D.D., Siderovski, D.P., Tarrant, T.K.

Journal:

Journal of Allergy and Clinical Immunology

Année:

2012

Langue:

english

Fichier:

PDF, 42 KB

english, 2012

Whither Goest the RGS Proteins?

Siderovski, David P., Strockbine, Bentley, Behe, Cynthia I.

Journal:

Critical Reviews in Biochemistry and Molecular Biology

Année:

1999

Langue:

english

Fichier:

PDF, 637 KB

english, 1999

Structural Determinants of RGS-RhoGEF Signaling Critical to Entamoeba histolytica Pathogenesis

Bosch, Dustin E., Kimple, Adam J., Manning, Alyssa J., Muller, Robin E., Willard, Francis S., Machius, Mischa, Rogers, Stephen L., Siderovski, David P.

Journal:

Structure

Année:

2013

Langue:

english

Fichier:

PDF, 1.79 MB

english, 2013

G-protein signaling modulator-3, a gene linked to autoimmune diseases, regulates monocyte function and its deficiency protects from inflammatory arthritis

Giguère, Patrick M., Billard, Matthew J., Laroche, Geneviève, Buckley, Brian K., Timoshchenko, Roman G., McGinnis, Marcus W., Esserman, Denise, Foreman, Oded, Liu, Peng, Siderovski, David P., Tarrant,

Journal:

Molecular Immunology

Année:

2013

Langue:

english

Fichier:

PDF, 709 KB

english, 2013